section {
	display: grid;
	grid-template-columns: 2fr 1fr;
}

div:first-child {
	background-color: crimson;
	grid-column: 1 / span 2;
}

div:nth-child(2) {
	background-color: hotpink;
}

div:nth-child(3) {
	background-color: lightsalmon;
	grid-column: 2;
	grid-row: 2 / 4; /* Instead of span. */
}
body {
	font-family: sans-serif;
	padding: 20px;
}

section {
	background-color: gold;
}

div {
	background-color: tomato;
	border-bottom: 2px solid firebrick;
	border-right: 2px solid firebrick;
	padding: 5px;
}
<!DOCTYPE html>
<html>
	<head>
		<meta name="viewport" content="width=device-width, initial-scale=1">
		<link href="/assets/styles/reset.css" rel="stylesheet">
		<link href="setup.css" rel="stylesheet">
		<link href="style.css" rel="stylesheet">
	</head>
	<body>
		<section>
			<div>
				<p>Item 1 will span across the top</p>
			</div>
			<div>
				<p>Item 2 with a lot of text in it that takes up some space, again I am writing this manually for some reason, but we’re already here so I may as well just keep writing nonsense to increase the height and show the layout better</p>
			</div>
			<div>
				<p>Item 3 continues down the side</p>
			</div>
			<div>
				<p>Item 4 might also have enough text to wrap and add height</p>
			</div>
		</section>
	</body>
</html>